Threonine Is Catabolized by L-Threonine 3-Dehydrogenase and Threonine Dehydratase in Hepatocytes from Domestic Cats (Felis domestica)
نویسندگان
چکیده
منابع مشابه
Biodegradative Threonine Dehydratase by Glyoxylate"
A timeand concentration-dependent irreversible inactivation of the Escherichia coli biodegradative threonine dehydratase by glyoxylate is accompanied by enzyme aggregation, apparent covalent binding of 4 mol of glyoxylate/mol of aggregated species, and a displacement of the absorption maximum of the enzyme-bound pyridoxal phosphate from 413 to 388 nm (Park, L. S., and Datta, P. (1979) J Biol. C...
متن کاملRat liver L-threonine dehydrogenase.
L-threonine dehydrogenase (E.C.1.1.1.103) catalyzes the NAD+-dependent transformation of Lthreonine to 2-amino 3-0x0-butyric acid, which spontaneously loses CO2 with the final production of aminoacetone ( 1) The enzyme is present in several microorganisms as well as in the liver of vertebrates (2-6). We studied some properties of the rat liver enzyme, showing that the activity was strongly inhi...
متن کاملMetabolic homoeostasis of L-threonine in the normally-fed rat. Importance of liver threonine dehydrogenase activity.
Threonine dehydratase, threonine aldolase and threonine dehydrogenase activities were assayed in livers of rats that had been normally-fed, starved for 72 h, fed a high-protein diet or normally-fed and injected with glucagon or cortisone. A modified continuous spectrophotometric assay for threonine aldolase overcame interference resulting from threonine dehydratase activity and revealed that th...
متن کاملMolecular Evolution of Threonine Dehydratase in Bacteria
Threonine dehydratase converts L-threonine to 2-ketobutyrate. Several threonine dehydratases exist in bacteria, but their origins and evolutionary pathway are unknown. Here we analyzed all the available threonine dehydratases in bacteria and proposed an evolutionary pathway leading to the genes encoding three different threonine dehydratases CTD, BTD1 and BTD2. The ancestral threonine dehydrata...
متن کاملEnzymatic Breakdown of Threonine by Threonine Aldolase
1. The enzyme which splits threonine to acetaldehyde and glycine has been partially purified from rat liver (five- to sixfold purification) and the name threonine aldolase proposed for it. 2. The general properties of threonine aldolase have been studied. The enzyme is unstable to a pH below 5. The pH optimum of the enzyme reaction is at 7.5-7.7. The initial rate of production of acetaldehyde i...
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ژورنال
عنوان ژورنال: The Journal of Nutrition
سال: 1996
ISSN: 0022-3166,1541-6100
DOI: 10.1093/jn/126.9.2218